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What to do when CRYSVITA arrives

Accepting and storing CRYSVITA properly will help you stay on track.

Here’s what will happen once you’ve been approved to start CRYSVITA

Your specialty pharmacy will inform you when your medication will be delivered
It’s important that you pick up or accept delivery on time and refrigerate it properly

NOTE: Without proper refrigeration, your medication may not be as effective, and your treatment schedule may be interrupted.

Don’t delay scheduling your first dose

Set up your injection appointment promptly when you receive your medication
Your dose is unique to you and will be administered as prescribed by a healthcare professional

If you miss a dose, be sure to receive your next CRYSVITA dose as soon as possible. To avoid missed doses, CRYSVITA may be given up to 3 days before or after the scheduled treatment date.

Vials of different doses of CRYSVITA

Not actual size

It’s important to stick to your CRYSVITA dosing schedule as prescribed.

Proper storage and handling of CRYSVITA

Once you have your medication at home, follow these instructions for storing and handling CRYSVITA:

CRYSVITA vials must be kept refrigerated at 36ºF to 46ºF (2ºC to 8ºC) in the original carton until it’s time to use it
Keep the CRYSVITA vial in the original carton to protect it from light until time of use
Do not freeze or shake CRYSVITA
Do not use CRYSVITA after the expiration date stamped on the carton
CRYSVITA vials are single dose only. Discard any unused product

If you have any questions about the storage and handling of CRYSVITA, contact your specialty pharmacy.

Have questions on receiving CRYSVITA and how to store it?

Connect with a Kyowa Kirin Cares case manager to help you understand what to expect.

Ready to talk to your doctor about CRYSVITA?

Getting started with CRYSVITA

What you need to know before starting CRYSVITA treatment

Find helpful CRYSVITA resources

Tools that can support your CRYSVITA journey

CRYSVITA frequently asked questions

Get answers to your CRYSVITA questions

Stay informed

Learn more about CRYSVITA, connect with a support community, and receive invites to important educational events.

What is CRYSVITA?

CRYSVITA is a prescription medicine used to treat adults and children 2 years of age and older with fibroblast growth factor 23 (FGF23)–related hypophosphatemia in tumor-induced osteomalacia (TIO) when the tumor cannot be located or removed.

What is CRYSVITA?

CRYSVITA is a prescription medicine used to treat adults and children 2 years of age and older with fibroblast growth factor 23 (FGF23)–related hypophosphatemia in tumor-induced osteomalacia (TIO) when the tumor cannot be located or removed.

Important Safety Information

You should not take CRYSVITA if:

You take an oral phosphate supplement and/or a specific form of vitamin D supplement (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).

Your phosphorus levels from a blood sample are within or above the normal range for age.
You have kidney problems.

What is the most important information you should know about CRYSVITA?

Some patients developed allergic reactions (e.g., rash and hives) while taking CRYSVITA. Your doctor will monitor you for symptoms of an allergic reaction while you are taking CRYSVITA.
High levels of phosphorus in the blood have been reported in some patients taking CRYSVITA. This may be related to a risk of high calcium levels in the kidneys. Your doctor will collect blood samples to monitor your levels.
Administration of CRYSVITA may result in reactions at the injection site, such as hives, reddening of the skin, rash, swelling, bruising, pain, severe itching of the skin, and collection of blood outside of a blood vessel (i.e., hematoma).
If you are taking CRYSVITA for TIO, your doctor will have you stop your CRYSVITA treatment temporarily if you are undergoing treatment for your tumor (e.g., surgical removal of the tumor or radiation therapy).

What are the possible side effects of CRYSVITA?

Adverse reactions that were seen in adults with TIO are:
- Tooth abscess
- Muscle spasms
- Dizziness
- Constipation
- Injection site reaction
- Rash
- Headache

Before taking CRYSVITA, tell your doctor about all of your medications (including supplements) and medical conditions, including if you:

Are taking oral phosphate and/or active vitamin D (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
Are pregnant, think you may be pregnant, or plan to become pregnant. There is not enough experience to know if CRYSVITA may harm your unborn baby. Report pregnancies to the Kyowa Kirin, Inc. Adverse Event reporting line at 1-844-768-3544.
Are breastfeeding or plan to breastfeed. There is not enough experience to know if CRYSVITA passes into your breast milk. Talk with your doctor about the best way to feed your baby while you receive CRYSVITA.

While taking CRYSVITA, tell your doctor if you experience:

An allergic reaction such as rash or hives
A rash, swelling, bruising, or other reaction at the injection site
New or worsening restless legs syndrome

These are not all the possible side effects of CRYSVITA. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Kyowa Kirin, Inc. at 1-844-768-3544.

For important risk and use information, please see the full Prescribing Information.

What is CRYSVITA?

CRYSVITA is a prescription medicine used to treat adults and children 2 years of age and older with fibroblast growth factor 23 (FGF23)–related hypophosphatemia in tumor-induced osteomalacia (TIO) when the tumor cannot be located or removed.

Important Safety Information

You should not take CRYSVITA if:

You take an oral phosphate supplement and/or a specific form of vitamin D supplement (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
Your phosphorus levels from a blood sample are within or above the normal range for age.
You have kidney problems.

What is the most important information you should know about CRYSVITA?

Some patients developed allergic reactions (e.g., rash and hives) while taking CRYSVITA. Your doctor will monitor you for symptoms of an allergic reaction while you are taking CRYSVITA.
High levels of phosphorus in the blood have been reported in some patients taking CRYSVITA. This may be related to a risk of high calcium levels in the kidneys. Your doctor will collect blood samples to monitor your levels.
Administration of CRYSVITA may result in reactions at the injection site, such as hives, reddening of the skin, rash, swelling, bruising, pain, severe itching of the skin, and collection of blood outside of a blood vessel (i.e., hematoma).
If you are taking CRYSVITA for TIO, your doctor will have you stop your CRYSVITA treatment temporarily if you are undergoing treatment for your tumor (e.g., surgical removal of the tumor or radiation therapy).

What are the possible side effects of CRYSVITA?

Adverse reactions that were seen in adults with TIO are:
- Tooth abscess
- Muscle spasms
- Dizziness
- Constipation
- Injection site reaction
- Rash
- Headache

Before taking CRYSVITA, tell your doctor about all of your medications (including supplements) and medical conditions, including if you:

Are taking oral phosphate and/or active vitamin D (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
Are pregnant, think you may be pregnant, or plan to become pregnant. There is not enough experience to know if CRYSVITA may harm your unborn baby. Report pregnancies to the Kyowa Kirin, Inc. Adverse Event reporting line at 1-844-768-3544.
Are breastfeeding or plan to breastfeed. There is not enough experience to know if CRYSVITA passes into your breast milk. Talk with your doctor about the best way to feed your baby while you receive CRYSVITA.

While taking CRYSVITA, tell your doctor if you experience:

An allergic reaction such as rash or hives
A rash, swelling, bruising, or other reaction at the injection site
New or worsening restless legs syndrome

These are not all the possible side effects of CRYSVITA. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Kyowa Kirin, Inc. at 1-844-768-3544.

For important risk and use information, please see the full Prescribing Information.