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Helpful resources

CRYSVITA patient resources

Explore the following resources to learn more about CRYSVITA and how it can help you manage your XLH.

Brochure for adults with XLH

This helpful brochure is for adults with XLH who want to learn more about how CRYSVITA treats XLH.

Download

Brochure for caregivers of children with XLH

This helpful brochure is for caregivers of children with XLH who want to learn more about how CRYSVITA treatment may be able to help their child.

Download

CRYSVITA doctor discussion guide for adults

Use this doctor discussion guide to help you prepare for your visit. That way, you can have a better conversation about whether CRYSVITA is right for you.

Download

CRYSVITA doctor discussion guide for caregivers

Use this doctor discussion guide to help you prepare for your child’s visit. That way, you can have a better conversation about whether CRYSVITA is right for your child.

Download

CRYSVITA family support guide

Encourage your loved ones to find out how CRYSVITA could help treat XLH and to talk to their doctor. This discussion guide can help you start the conversation.

Download

Join us at educational events for patients and caregivers

Join us at an event to learn more about CRYSVITA for XLH. When you do, you will hear from an XLH specialist and a patient or caregiver about their experience with XLH. You’ll also have a chance to connect with others in the XLH community.

Find an event near you.

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Connect with others in the XLH community

Even though XLH may be rare, you’re not alone. The groups listed below provide support and education for people living with XLH.

Kyowa Kirin is a proud sponsor of The XLH Network, NORD, and their goals.

The XLH Network

The XLH Network, a 501(c)(3) nonprofit organization, seeks to connect people around the world who are affected by or interested in learning more about XLH. The XLH Network connects affected individuals, families, and medical professionals.

National Organization for Rare Disorders (NORD)

NORD is a patient advocacy organization dedicated to individuals with rare diseases and the organizations that serve them.

Global Genes

Global Genes is a rare disease patient advocacy organization that works to build awareness, educate the global community, and provide connections and resources.

Explore more resources just for you

Learn more about CRYSVITA support

See how the CRYSVITA support programs may help you or your child

CRYSVITA frequently asked questions

Get answers to your questions about CRYSVITA

Hear from people taking CRYSVITA

Experience real stories of people with XLH and their journeys with CRYSVITA

Stay informed

Learn more about CRYSVITA, connect with a support community, and receive invites to important educational events.

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What is CRYSVITA?

CRYSVITA is a prescription medicine used to treat adults and children 6 months of age and older with X-linked hypophosphatemia (XLH).

What is CRYSVITA?

CRYSVITA is a prescription medicine used to treat adults and children 6 months of age and older with X-linked hypophosphatemia (XLH).

Important Safety Information

You should not take CRYSVITA if:

  • You take an oral phosphate supplement and/or a specific form of vitamin D supplement (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
  • Your phosphorus levels from a blood sample are within or above the normal range for age.
  • You have kidney problems.

What is the most important information you should know about CRYSVITA?

  • Some patients developed allergic reactions (e.g., rash and hives) while taking CRYSVITA. Your doctor will monitor you for symptoms of an allergic reaction while you are taking CRYSVITA. Your treatment may need to be discontinued for serious allergic reactions.
  • High levels of phosphorus in the blood have been reported in some patients taking CRYSVITA. This may be related to a risk of high calcium levels in the kidneys. Your doctor will collect blood samples to monitor your levels. If you are already taking CRYSVITA, dose interruption and/or dose reduction may be required based on your serum phosphorus levels.
  • Administration of CRYSVITA may result in reactions at the injection site, such as hives, reddening of the skin, rash, swelling, bruising, pain, severe itching of the skin, and collection of blood outside of a blood vessel (i.e., hematoma). Call your doctor if you develop an injection site reaction. CRYSVITA may be discontinued if severe injection site reactions occur.

What are the possible side effects of CRYSVITA?

  • Adverse reactions that were seen in children with XLH are:

    • Fever
    • Injection site reaction
    • Cough
    • Vomiting
    • Pain in arms and legs
    • Headache
    • Tooth abscess
    • Dental cavities
    • Diarrhea
    • Decreased vitamin D levels
    • Toothache
    • Constipation
    • Muscle pain
    • Rash
    • Dizziness
    • Nausea

  • Adverse reactions that were seen in adults with XLH are:

    • Back pain
    • Headache
    • Tooth infection
    • Restless legs syndrome
    • Decreased vitamin D levels
    • Dizziness
    • Constipation
    • Muscle spasms
    • Phosphorus levels increased in the blood
  • Narrowing of the spaces within the spine is common in adults with XLH, and pressure on the spinal cord has been reported in adults taking CRYSVITA. It is not known if taking CRYSVITA worsens the narrowing of the spaces within the spine or the pressure on the spinal cord.

Before taking CRYSVITA, tell your doctor about all of your medications (including supplements) and medical conditions, including if you:

  • Are taking oral phosphate and/or active vitamin D (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
  • Are pregnant, think you may be pregnant, or plan to become pregnant. There is not enough experience to know if CRYSVITA may harm your unborn baby. Report pregnancies to the Kyowa Kirin, Inc. Adverse Event reporting line at 1-844-768-3544.
  • Are breastfeeding or plan to breastfeed. There is not enough experience to know if CRYSVITA passes into your breast milk. Talk with your doctor about the best way to feed your baby while you receive CRYSVITA.

While taking CRYSVITA, tell your doctor if you experience:

  • An allergic reaction such as rash or hives
  • A rash, swelling, bruising, or other reaction at the injection site
  • New or worsening restless legs syndrome

These are not all the possible side effects of CRYSVITA. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Kyowa Kirin, Inc. at 1-844-768-3544.

For important risk and use information, please see the full Prescribing Information.

What is CRYSVITA?

CRYSVITA is a prescription medicine used to treat adults and children 6 months of age and older with X-linked hypophosphatemia (XLH).

Important Safety Information

You should not take CRYSVITA if:

  • You take an oral phosphate supplement and/or a specific form of vitamin D supplement (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
  • Your phosphorus levels from a blood sample are within or above the normal range for age.
  • You have kidney problems.

What is the most important information you should know about CRYSVITA?

  • Some patients developed allergic reactions (e.g., rash and hives) while taking CRYSVITA. Your doctor will monitor you for symptoms of an allergic reaction while you are taking CRYSVITA. Your treatment may need to be discontinued for serious allergic reactions.
  • High levels of phosphorus in the blood have been reported in some patients taking CRYSVITA. This may be related to a risk of high calcium levels in the kidneys. Your doctor will collect blood samples to monitor your levels. If you are already taking CRYSVITA, dose interruption and/or dose reduction may be required based on your serum phosphorus levels.
  • Administration of CRYSVITA may result in reactions at the injection site, such as hives, reddening of the skin, rash, swelling, bruising, pain, severe itching of the skin, and collection of blood outside of a blood vessel (i.e., hematoma). Call your doctor if you develop an injection site reaction. CRYSVITA may be discontinued if severe injection site reactions occur.

What are the possible side effects of CRYSVITA?

  • Adverse reactions that were seen in children with XLH are:

    • Fever
    • Injection site reaction
    • Cough
    • Vomiting
    • Pain in arms and legs
    • Headache
    • Tooth abscess
    • Dental cavities
    • Diarrhea
    • Decreased vitamin D levels
    • Toothache
    • Constipation
    • Muscle pain
    • Rash
    • Dizziness
    • Nausea

  • Adverse reactions that were seen in adults with XLH are:

    • Back pain
    • Headache
    • Tooth infection
    • Restless legs syndrome
    • Decreased vitamin D levels
    • Dizziness
    • Constipation
    • Muscle spasms
    • Phosphorus levels increased in the blood
  • Narrowing of the spaces within the spine is common in adults with XLH, and pressure on the spinal cord has been reported in adults taking CRYSVITA. It is not known if taking CRYSVITA worsens the narrowing of the spaces within the spine or the pressure on the spinal cord.

Before taking CRYSVITA, tell your doctor about all of your medications (including supplements) and medical conditions, including if you:

  • Are taking oral phosphate and/or active vitamin D (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
  • Are pregnant, think you may be pregnant, or plan to become pregnant. There is not enough experience to know if CRYSVITA may harm your unborn baby. Report pregnancies to the Kyowa Kirin, Inc. Adverse Event reporting line at 1-844-768-3544.
  • Are breastfeeding or plan to breastfeed. There is not enough experience to know if CRYSVITA passes into your breast milk. Talk with your doctor about the best way to feed your baby while you receive CRYSVITA.

While taking CRYSVITA, tell your doctor if you experience:

  • An allergic reaction such as rash or hives
  • A rash, swelling, bruising, or other reaction at the injection site
  • New or worsening restless legs syndrome

These are not all the possible side effects of CRYSVITA. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Kyowa Kirin, Inc. at 1-844-768-3544.

For important risk and use information, please see the full Prescribing Information.