The importance of staying on CRYSVITA
XLH is a chronic, progressive disease and if left untreated, symptoms can get worse
That’s why it is important that every child with XLH has an established, consistent care plan that meets their needs.
Taking CRYSVITA as prescribed may help manage your child’s XLH
It’s important that your child receives CRYSVITA exactly as prescribed and does not miss a dose unless directed by their doctor.
When you talk to the doctor about CRYSVITA, make sure to discuss strategies that can help you and your child stick with their treatment routine at every stage of life.
Make sure you have a plan to help your child stay on CRYSVITA during all of life's changes
Some life changes are bigger than others, especially during transitional stages of life. But with some preparation, these changes don’t have to feel so overwhelming for you or your child.
These changes could include:
- Outgrowing their pediatric doctor (for adolescents)
- Moving to a new town
- Going to college
- Changing insurance providers
If your child has to change doctors for any reason, it's important to:
- Ask their current healthcare provider for help identifying another doctor who can continue to provide CRYSVITA
- Clearly communicate with their new doctor about how CRYSVITA may be helping them
- Discuss treatment goals for your child's XLH
- Have a conversation about what is, and what is not, working regarding their XLH treatment
CRYSVITA only works to treat XLH as long as your child continues to receive it as prescribed. That’s why it’s important to stick to their treatment plan.
Have questions about changing doctors or insurance?
Connect with a Kyowa Kirin Cares case manager, who can help you access resources.
Get support and resources for your child’s CRYSVITA journey
Stay informed
Learn more about CRYSVITA, connect with a support community, and receive invites to important educational events.
CRYSVITA is a prescription medicine used to treat adults and children 6 months of age and older with X-linked hypophosphatemia (XLH).
You should not take CRYSVITA if:
- You take an oral phosphate supplement and/or a specific form of vitamin D supplement (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
- Your phosphorus levels from a blood sample are within or above the normal range for age.
- You have kidney problems.
What is the most important information you should know about CRYSVITA?
- Some patients developed allergic reactions (e.g., rash and hives) while taking CRYSVITA. Your doctor will monitor you for symptoms of an allergic reaction while you are taking CRYSVITA. Your treatment may need to be discontinued for serious allergic reactions.
- High levels of phosphorus in the blood have been reported in some patients taking CRYSVITA. This may be related to a risk of high calcium levels in the kidneys. Your doctor will collect blood samples to monitor your levels. If you are already taking CRYSVITA, dose interruption and/or dose reduction may be required based on your serum phosphorus levels.
- Administration of CRYSVITA may result in reactions at the injection site, such as hives, reddening of the skin, rash, swelling, bruising, pain, severe itching of the skin, and collection of blood outside of a blood vessel (i.e., hematoma). Call your doctor if you develop an injection site reaction. CRYSVITA may be discontinued if severe injection site reactions occur.
What are the possible side effects of CRYSVITA?
-
Adverse reactions that were seen in children with XLH are:
- Fever
- Injection site reaction
- Cough
- Vomiting
- Pain in arms and legs
- Headache
- Tooth abscess
- Dental cavities
- Diarrhea
- Decreased vitamin D levels
- Toothache
- Constipation
- Muscle pain
- Rash
- Dizziness
- Nausea
-
Adverse reactions that were seen in adults with XLH are:
- Back pain
- Headache
- Tooth infection
- Restless legs syndrome
- Decreased vitamin D levels
- Dizziness
- Constipation
- Muscle spasms
- Phosphorus levels increased in the blood
- Narrowing of the spaces within the spine is common in adults with XLH, and pressure on the spinal cord has been reported in adults taking CRYSVITA. It is not known if taking CRYSVITA worsens the narrowing of the spaces within the spine or the pressure on the spinal cord.
Before taking CRYSVITA, tell your doctor about all of your medications (including supplements) and medical conditions, including if you:
- Are taking oral phosphate and/or active vitamin D (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
- Are pregnant, think you may be pregnant, or plan to become pregnant. There is not enough experience to know if CRYSVITA may harm your unborn baby. Report pregnancies to the Kyowa Kirin, Inc. Adverse Event reporting line at 1-844-768-3544.
- Are breastfeeding or plan to breastfeed. There is not enough experience to know if CRYSVITA passes into your breast milk. Talk with your doctor about the best way to feed your baby while you receive CRYSVITA.
While taking CRYSVITA, tell your doctor if you experience:
- An allergic reaction such as rash or hives
- A rash, swelling, bruising, or other reaction at the injection site
- New or worsening restless legs syndrome
These are not all the possible side effects of CRYSVITA. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Kyowa Kirin, Inc. at 1-844-768-3544.
For important risk and use information, please see the full Prescribing Information.
CRYSVITA is a prescription medicine used to treat adults and children 6 months of age and older with X-linked hypophosphatemia (XLH).
You should not take CRYSVITA if:
- You take an oral phosphate supplement and/or a specific form of vitamin D supplement (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
- Your phosphorus levels from a blood sample are within or above the normal range for age.
- You have kidney problems.
What is the most important information you should know about CRYSVITA?
- Some patients developed allergic reactions (e.g., rash and hives) while taking CRYSVITA. Your doctor will monitor you for symptoms of an allergic reaction while you are taking CRYSVITA. Your treatment may need to be discontinued for serious allergic reactions.
- High levels of phosphorus in the blood have been reported in some patients taking CRYSVITA. This may be related to a risk of high calcium levels in the kidneys. Your doctor will collect blood samples to monitor your levels. If you are already taking CRYSVITA, dose interruption and/or dose reduction may be required based on your serum phosphorus levels.
- Administration of CRYSVITA may result in reactions at the injection site, such as hives, reddening of the skin, rash, swelling, bruising, pain, severe itching of the skin, and collection of blood outside of a blood vessel (i.e., hematoma). Call your doctor if you develop an injection site reaction. CRYSVITA may be discontinued if severe injection site reactions occur.
What are the possible side effects of CRYSVITA?
-
Adverse reactions that were seen in children with XLH are:
- Fever
- Injection site reaction
- Cough
- Vomiting
- Pain in arms and legs
- Headache
- Tooth abscess
- Dental cavities
- Diarrhea
- Decreased vitamin D levels
- Toothache
- Constipation
- Muscle pain
- Rash
- Dizziness
- Nausea
-
Adverse reactions that were seen in adults with XLH are:
- Back pain
- Headache
- Tooth infection
- Restless legs syndrome
- Decreased vitamin D levels
- Dizziness
- Constipation
- Muscle spasms
- Phosphorus levels increased in the blood
- Narrowing of the spaces within the spine is common in adults with XLH, and pressure on the spinal cord has been reported in adults taking CRYSVITA. It is not known if taking CRYSVITA worsens the narrowing of the spaces within the spine or the pressure on the spinal cord.
Before taking CRYSVITA, tell your doctor about all of your medications (including supplements) and medical conditions, including if you:
- Are taking oral phosphate and/or active vitamin D (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
- Are pregnant, think you may be pregnant, or plan to become pregnant. There is not enough experience to know if CRYSVITA may harm your unborn baby. Report pregnancies to the Kyowa Kirin, Inc. Adverse Event reporting line at 1-844-768-3544.
- Are breastfeeding or plan to breastfeed. There is not enough experience to know if CRYSVITA passes into your breast milk. Talk with your doctor about the best way to feed your baby while you receive CRYSVITA.
While taking CRYSVITA, tell your doctor if you experience:
- An allergic reaction such as rash or hives
- A rash, swelling, bruising, or other reaction at the injection site
- New or worsening restless legs syndrome
These are not all the possible side effects of CRYSVITA. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Kyowa Kirin, Inc. at 1-844-768-3544.
For important risk and use information, please see the full Prescribing Information.